As the Pharma 4.0 initiative sets a new industry paradigm, more biomanufacturing companies are asking how they can design and build facilities that apply risk-based thinking to manufacturing innovation. In this article, new CDMO Wheeler Bio discusses how Pharma 4.0 can increase accuracy and decrease risk, the challenges that come with shifting industry perceptions, moving from a paper model to digitalized, integrated systems, and Wheeler's design and build plans for their Oklahoma City headquarters.