For many years cylindrical stainless steel tanks have been used in biopharmaceutical production.
The primary reason for the cylindrical shape was that it provided the mechanical stability required for high-pressure steam sterilization.
As single-use bioreactor vessels were developed, they adopted the same cylindrical shape as their stainless steel counterparts.
Pall recently traded the traditional geometry for the cube shape Allegro™ STR single-use bioreactors.
Their innovative cube shape offers unique features not possible in a cylindrical design.
This technical publication discusses the many advantages of a square bioreactor compared with the traditional cylindrical design.