The collaboration will see TiCARos generate a range of CLIP-CAR (Clamping-based Immunological Synapse Potentiating CAR) constructs and provide them to Cartherics to incorporate into its NK cells, and then assess their in vitro and in vivo function.
TiCARos is developing novel chimeric antigen receptor (CAR)-T cell products for the treatment of solid and blood cancers incorporating its CLIP-CAR approach.
The CLIP component stabilises the immune synapse between immune cells and target tumour cells by modifying the CAR structure, thereby improving the contact between CAR-T cells and tumour cells, resulting in enhanced efficacy in vitro and in vivo models.
Cartherics’ CEO, Professor Alan Trounson, commented: “Bringing new cutting-edge technologies such as CLIP-CAR together with Cartherics’ allogeneic NK cell platform is an exciting development that may make these therapies even more effective.
“We continue to work collaboratively with innovative companies and academics internationally to build a leading portfolio of therapeutic products in cancer. An effective CLIP-CAR targeting tissue factor could provide the basis of a CAR-NK product for triple negative breast cancer and other difficult to treat cancers."
Each company has nominated a tumour antigen it wishes to target in assessment of the CARs.
Cartherics’ target is tissue factor (TF), a target for which it recently entered into an option agreement with The Ohio State University, while TiCARos will be assessing CD19 as its tumour target.
“We are excited to extend the application of our CLIP CAR-T platform technology into CAR-NK therapeutic approach by collaborating with Cartherics, as their expertise lies in the field of allogeneic cell platform based upon iPSC-derived NK cell therapy,” said JW Lee, CEO of TiCARos.
“We see a remarkable opportunity to leverage our core capabilities, accelerate pipeline programs, and expand opportunities beyond autologous cell therapies,” and added “this collaboration creates a path for accelerating our respective solid tumor pipeline programs and broadening the use of TiCARos’ technology outside of autologous cell therapy applications.”
Subject to the results from the research collaboration, Cartherics and TiCARos will negotiate a development and commercialisation agreement.
