CytoSMART Technologies has released its first fluorescence cell counter, CytoSMART Exact FL.
An automated, dual fluorescence cell counter, it has an expanded field of view that calculates the exact number of cells in a sample, said the company.
It is designed to provide a reliable assessment of key cellular parameters including cell viability and transfection efficiency.
The cell counter sets new standards in terms of accuracy, speed, and performance: improved specifications include an advanced 6.4-megapixel CMOS camera, and also ultrafast autofocus, high magnification and high contrast lenses, increased measuring volume, and super robust image recognition by Artificial Intelligence (AI) algorithms, said the developer.
“The CytoSMART Exact FL can count cells using a bright-field channel, while simultaneously assessing viability and transfection efficiency with two fluorescent channels. It can also ease the counting of hard-to-detect primary cells or quantify multiple cell types in one sample. Another fascinating feature of our devices is the introduction of add-on modules, which enable customers to expand the application range of their device allowing them to also count organoids,” said Joffry Maltha, CEO, CytoSMART Technologies.
Thermo Fisher Scientific has launched a CO2 incubator that it says combines optimal cell growth capabilities with certified cleanroom compatibility. It is meant to effectively address the growing need among biotech, biopharma and clinical laboratories for high-performance incubation systems that meet stringent cleanroom and cGMP standards.
"As innovative research is being rapidly translated into promising therapies, we have seen dramatic growth in demand for premium incubators that are suitably equipped for use in controlled environments. To effectively meet this need, we have complemented the demonstrated recovery and uniformity capabilities of the Thermo Scientific Heracell VIOS CO2 Incubator and Thermo Scientific Forma Steri-Cycle CO2 incubators with exceptional cleanability and GMP-enabling features to deliver the first CO2 incubator that is specifically built for cleanroom use.
“This marks the latest step in our journey to better support cell therapy developers as they seek to bring innovative new therapeutics to patients,” said said Douglas Wernerspach, senior business director, laboratory products division at Thermo Fisher Scientific.
The Heracell Vios CR CO2 Incubator provides optimal cell growth for even the most sensitive high-value cell cultures, said the company.
It comprises fully enclosed casing and electronics, minimizing particle emissions in sync with critical particulate control in a Grade A/B cleanroom.
Operating on the patented Thermo Scientific THRIVE active airflow technology, which the developer says delivers homogenous cell growth conditions and rapid parameter recovery in under 10 minutes, the system prioritizes cell culture protection.
Dependable contamination control is enabled through in-chamber HEPA filtration, on-demand 180°C sterilization and an optional 100% pure copper interior chamber, it added.
The incubator also has a robust stainless-steel exterior and IP54-compliant design; it is built to withstand rigorous and repeated cleaning procedures that are integral to effective cleanroom management “enabling long-term use and maximum return on investment.”
3M Health Care recently launched the 3M Polisher ST, a single-use AEX solution designed to replace reusable AEX polishing column for biologic drug manufacturing.
The developer said Polisher ST improves the biopharma manufacturing workflow by reducing the number of processing steps thereby helping to improve process economics.
A synthetic, fully encapsulated, single-use membrane chromatography solution, it contains two complementary AEX-functional media: a quaternary ammonium (Q) functional nonwoven and a guanidinium-functional membrane.
The equipment can be used in continuous bioprocessing: It is a single-use technology designed as a cost-efficient option to increase biomass production in therapeutic recombinant protein processes in all operating conditions; and to replace downstream AEX polishing column in fed batch and/or continuous manufacturing.
"3M Polisher ST is designed as a next-generation bioprocessing solution for process intensification in both large, dedicated product sites and small multi-product manufacturing facilities," said Robert Befidi, Jr, division vice president, 3M Separation and Purification Sciences. "This product will be particularly suitable for facilities of the future which will be smaller in size and capable of producing significantly higher product volumes.”
Aigenpulse has rolled out an update to its CytoML Experiment Suite – an automated, end-to-end, machine learning solution specifically aimed at streamlining and automating flow cytometry analysis at scale and replacing manual gating processes. The company said the technology can help increase throughput of data processing and analytics by as much as 600%.
Researchers need reproducible data to support a regulatory filing, said Aigenpulse. The latest release of the CytoML Suite (v5.2) introduces new unbiased analysis features that can help uncover new insights by finding novel populations or clustering non-intuitive populations together, it said.
Unbiased analysis tools allow complex multi-dimensional flow cytometry data to be simplified, unified, processed and visualized so that it can be more easily explored and compared, said the developer.
Cherwell Laboratories recently introduced new models to the ImpactAir range of microbial air monitors that it distributes for Pinpoint Scientific.
The now extended ImpactAir-ISO-90 and the new ImpactAir-90 ranges aim to support the new EU GMP Annex 1 requirements for continuous environmental monitoring (EM).
The distributor said the equipment is designed to be used in high-grade areas within the pharmaceutical, healthcare and specialist food industries, where process monitoring of viable particles can be critical and where ISO-14698, BS EN 17141 and GMP Annex 1 compliance must be satisfied.
The monitoring platform used within both the ImpactAir-ISO-90 and ImpactAir-90 ranges meets the stringent requirements of these regulations whilst offering a range of flexible solutions that can be tailored to meet end users’ specific needs, said the company.
“Benefits are gained from use of common components and user interfaces throughout both model ranges. This cuts operator training requirements, reduces risk, streamlines regulator audits, simplifies product support and calibration, and allows data from different areas to be compared on the same baseline.”
Thermo Fisher Scientific also recently launched its new KingFisher Apex Purification System, a high-throughput sample purification instrument designed to automate the extraction of DNA, RNA, proteins, and cells from an array of sample types.
The KingFisher Apex is said to enable nucleic acid, protein, and cell isolation while also allowing users to customize protocols directly from the instrument. The system can process 24 to 96 samples in 25 to 65 minutes and elutes in low volumes (10 µL) for demanding downstream applications.
The company outlines how the system has a touchscreen and is enabled with heating and cooling controls, dual ultraviolet (UV) lights, cloud-enabled access, and dual magnets to support small and large volume ranges.
"Building on decades of product expertise, the KingFisher Apex combines unparalleled instrument capabilities into one platform, filling a gap where existing solutions include either large, complicated, high-cost instruments or low-throughput solutions that don't meet the processing needs of many labs," said Jeff Journey, vice president and general manager of sample preparation at Thermo Fisher Scientific.
Immudex ApS has been collaborating with Becton, Dickinson and Company (BD) to create improved solutions for T-cell multi-omics research.
That work led to the launch of dCODE Dextramer (RiO) reagents in February this year. These DNA barcoded MHC Dextramer reagents are designed to be compatible with the BD Rhapsody system to be used for multiplexing, allowing the identification of many different T-cell specificities in the same sample. Creating personalized dCODE Dextramer libraries, it is possible to profile T cells and get a new understanding of T-cell immunity, said the developer.
Liselotte Brix, CSO at Immudex, commented: “The immune system is complex, and there is still a lot to be discovered. dCODE Dextramer (RiO) technology combined with the BD Rhapsody single-cell multi-omic analysis provides a deeper understanding of T cell immunology in a user-friendly workflow by combining information on TCR recognition with gene and surface marker expression at the single-cell level. Such information helps unlock new insights into the immune response, accelerating basic research, immunotherapeutic development, and improving patient outcomes."
