UK gives $31m to industry-academic biodevelopment collabs

The UK has granted £20m ($31m) to the biotech industry – including Horizon, FujiFilm, and Cobra Biologics, to bring mAb, cell expression, and antibiotic projects to market.

Business Secretary Vince Cable unveiled 23 winners of a competition to support collaboration between researchers and biotech businesses in the United Kingdom.

Speaking during a visit to Ingenza, a contract manufacturer and services provider for biopharma companies based in Edinburgh, Scotland, Cable said developing new antibiotics is one of the aims of the Indstrial Biotechnology Catalyst grants.

Ingenza was awarded £680,000 for research which includes the aim to discover a new class of antibiotics.

MD Ian Fotheringhamsaid the company uses “innovative synthetic biology tools to increase the speed, scale, and predictability with which we can build or redesign biological systems for commercial applications. Dr Cable's visit is a much appreciated boost to our efforts to contribute to job growth in the UK's burgeoning industrial biotechnology sector."

The winning projects

Twenty-three awardees received a share of the £20m fund, with an emphasis on biopharmaceutical projects and the life sciences industry. Prize money also went to research into chemistry, biofuels, and plastics.

  1. A new generation of E. coli expression hosts and tools for recombinant protein production
  2.  University of Kent
  3. A Combinatorial Approach to Enhance Production of Monoclonal Antibodies
  4.  University of York
  5. Developing platforms for the production of diterpenoids
  6.  University of York
  7. Manufacture of complex protein polymers for industry and medicine
  8.  Newcastle University
  9. Improved downstream operation through formulation innovation
  10.  Arecor/Centre for Process Innovation (CPI)/ FujiFilm Diosynth Biotechnologies
  11. Bioplastic polymers based on aromatic dicarboxylic acids derived from lignin
  12.  Biome Technologies/ CPI/ University of Warwick/University of Leeds
  13. ALGIPRO - Alginates by Production Scale Fermentation and Epimerisation
  14.  CPI/AlgiPharma/ FMC Biopolymer
  15. Combinatorial genome editing to create enhanced biomanufacturing platforms
  16.  Horizon Discovery/CPI NBMC/ University of Manchester
  17. Efficient production of first in class antimicrobial therapeutics from an integrated synthetic biology approach
  18.  Ingenza/Plymouth University
  19. A naturally inspired industrial biotechnology route to the manufacture of a novel biopolymer with unique properties
  20.  Ingenza/ Synthomer
  21. Industrial validation of nanofibre platform technology for biotherapeutics manufacture
  22.  Puridify/UCL
  23. Much-efficient and cost-effective manufacturing of antibody biotherapeutics employing integrated negative chromatography technology
  24.  UCB/BioToolomics
  25. Development of superior Clostridial strains for low cost renewable chemical production
  26.  GreenBiologics
  27. Biochemical production of succinic acid from biorefinery glycerol: De-risking, scale-up, and feasibility
  28.  University of Manchester/CPI/ Brocklesby
  29. PeriTune - a clonal optimisation platform
  30.  University of Manchester/Cobra Biologics
  31. Development of new tools for de novo polyketide synthase design
  32.  Isomerase/University of Cambridge
  33. Generation of a library of recombineered novel polyketides and non-ribosomal peptides
  34.  Isomerase/ Biosyntha/ John Innes Centre
  35. Discovery and development of large/diverse user-friendly panels of novel biocatalysts
  36.  Prozomix/ Northumbria University
  37. Engineering a Nano-factory for Peptide Synthesis
  38.  Generon/ University of Bristol
  39. In vivo selection of bioprocessable biopharmaceuticals
  40.  University of Leeds/MedImmune/Avacta Analytical
  41. Novel production processes for L-glufosinate
  42.  Acidophil
  43. Novel platform biotechnology for the production of natural next generation 3D nanomaterials and nanodevices
  44.  Cellucomp/James Hutton Insitute/ Mylnefield Research
  45. Driving down the cost of waste derived sugar
  46.  Fiberight/CPI/Rebio Technologies/ University of Leeds/Aston/Knauf/novozymes

The prize money was provided by Biotechnology and Biological Sciences Research Council (BBSRC), Engineering and Physical Sciences Research Council and Innovate UK.